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Inventi Impact: Cardiology & Haematology

Articles

  • Inventi:hch/27995/19
    Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes
    Research 2019 : April - June
    Galina A Dudina, Almira D Donetskova, Marina M Litvina, Alexander N Mitin, Tatiana A Mitina, Sergey A Polyakov

    We have investigated the frequencies of regulatoryT cells and the level of FOXP3 isoforms expression in peripheral blood of patients\nwith myelodysplastic syndromes and found the significant reduction of regulatory T cells at all stages of the disease. At the same\ntime in untreated patients,we observed the shift in the FOXP3 isoforms expression profile towards the full-length molecule possibly\ndue to inflammation. Based on the already known information about the potentially higher functional activity of FOXP3molecule\nlacking exon 2, we have also hypothesized that our finding may explain the high risk of autoimmune disorders in this disease.

    How to Cite this Article
    CC Compliant Citation: Galina A. Dudina, Almira D. Donetskova,\nMarina M. Litvina, Alexander N. Mitin, Tatiana A. Mitina, and\nSergey A. Polyakov, â??Regulatory T Cells and Profile of FOXP3\nIsoforms Expression in Peripheral Blood of Patients with\nMyelodysplastic Syndromes,â? Advances in Hematology, vol. 2018,\nArticle ID 8487403, 8 pages, 2018. https://\ndoi.org/10.1155/2018/8487403, http://creativecommons.org/\nlicenses/by/4.0/.
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